Taking as a point of reference the recent document of the Pontifical Biblical Commission, Inspiration and Truth of Sacred Scripture, this article examines how the Gospel of John gives evidence of its inspiration by having its origin from God. Every reference to God is made through the person of Jesus. Therefore, the relationship between Jesus and his disciples is of fundamental importance for understanding the origin of this Gospel. Whereas abstract statements about inspiration can sometimes lead the reader in a false direction, the testimony of the Gospel itself is able to foster a suitable way of reading and approaching the Sacred Scriptures.